منابع مشابه
Hydrophobic interactions: an overview
We present an overview of the recent progress that has been made in understanding the origin of hydrophobic interactions. We discuss the different character of the solvation behaviour of apolar solutes at small and large length scales. We emphasize that the crossover in the solvation behaviour arises from a collective effect, which means that implicit solvent models should be used with care. We...
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Viruses are obligatory intracellular parasites that use cell proteins to take the control of the cell functions in order to accomplish their life cycle. Studying the viral-host interactions would increase our knowledge of the viral biology and mechanisms of pathogenesis. Studies on pathogenesis mechanisms of lyssaviruses, which are the causative agents of rabies, have revealed some important ho...
متن کاملAn information theory model of hydrophobic interactions.
A molecular model of poorly understood hydrophobic effects is heuristically developed using the methods of information theory. Because primitive hydrophobic effects can be tied to the probability of observing a molecular-sized cavity in the solvent, the probability distribution of the number of solvent centers in a cavity volume is modeled on the basis of the two moments available from the dens...
متن کاملUrea's action on hydrophobic interactions.
For more than a century, urea has been commonly used as an agent for denaturing proteins. However, the mechanism behind its denaturing power is still not well understood. Here we show by molecular dynamics simulations that a 7 M aqueous urea solution unfolds a chain of purely hydrophobic groups which otherwise adopts a compact structure in pure water. The unfolding process arises due to a weake...
متن کاملImportance of Hydrophobic Motif Interactions
INTRODUCTION The Serum and Glucocorticoid regulated kinases (SGK) are a family of serine/threonine protein kinases that show extensive sequence homology to the Protein Kinase B (PKB/Akt) enzymes. Three isoforms exist in humans: SGK1, SGK2 and SGK3. Like PKB, SGK1 acts downstream of phosphatidylinositol-3-kinase (PI3K) (1). PKB requires phosphorylation of its activation loop and of a hydrophobic...
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ژورنال
عنوان ژورنال: Journal of Physics: Condensed Matter
سال: 2002
ISSN: 0953-8984
DOI: 10.1088/0953-8984/14/40/328